DBT & BIRAC Publicizes Joint Name For Proposals Bio-AI

DBT & BIRAC Publicizes Joint Name For Proposals Bio-AI – Functions Invited On-line

DBT & BIRAC Publicizes Joint Name For Proposals Bio-AI – Functions Invited On-line. and eligible candidates can try the entire particulars on the identical under:

DBT BIRAC Joint Name for Proposals on Bio-AI for establishing मूलांकुर hubs below BioE3 Coverage for Biomanufacturing

Submit Drawback Statements and Analysis options as Idea Be aware (LoIs)

1. BACKGROUND

Division of Biotechnology (DBT) with the approval of the Cupboard has introduced the BioE3 (Biotechnology for Economic system, Setting and Employment) coverage for “Fostering Excessive-performance Biomanufacturing”. This initiative is supported below the Cupboard Authorised ‘Biotechnology Analysis Innovation and Entrepreneurship Improvement (Bio-RIDE)’ scheme to foster innovation, promote bio-entrepreneurship, and strengthen India’s place as a worldwide chief in Biomanufacturing and Biotechnology.

Bio-AI is likely one of the enablers for constructing data-driven, cutting-edge, programmatic analysis help for the Biomanufacturing initiative. The outcomes are anticipated to supply essential and novel analysis leads impacting Well being, Agriculture and Setting.

2. SCOPE OF THE CALL

The Bio-AI name invitations downside statements and analysis options in Biomolecular Design, Sustainable Agriculture, Artificial Biology, Ayurveda and Genomics Diagnostics to be addressed by multi-disciplinary groups with analysis experience throughout artificial biology, AI/ML, computation. LoIs ought to be submitted now and for shortlisted purposes, full-length proposal could be sought.

i) Biomolecular Design

• Engineering novel proteins, enzymes, and RNA-based molecules for superior biomedical and biotechnological purposes.

• Designing next-generation protein, and RNA-based antibodies for focused therapeutics and immune modulation.

• Growing superior enzyme inhibitors, RNA aptamers, and de novo enzyme designs for precision illness intervention and metabolic engineering.

• Developing bio-nanomachines and catalytic biomolecules with programmable molecular capabilities for diagnostics, therapeutics, and artificial biology purposes.

ii) Sustainable Agriculture

• Engineering drought-resistant cereal crops for enhanced local weather resilience

• Growing AI-powered, non-invasive sensing applied sciences (e.g., drone imaging, infrared spectroscopy) for early illness detection

• Predictive modeling of milk manufacturing and well being parameters in dairy cattle utilizing AI and genomics

iii) Artificial Biology

• AI optimized metabolic pathways for biofuel and biomaterial manufacturing.

• Predicting enzyme capabilities for extra environment friendly bioprocessing.

• Enhance pressure engineering for microbial factories.

• Artificial/engineered organisms as environmental biosensors

iv) Ayurveda

• AI-driven Ayurvedic Pharmacogenomics: Growing predictive fashions to personalize Ayurvedic therapies primarily based on genetic, metabolic, and microbiome profile

• AI-enabled Herb-Drug Interplay Evaluation: Figuring out potential interactions between Ayurvedic formulations and trendy prescribed drugs utilizing AI and molecular modelling.
• Standardization & Authentication of Ayurvedic Formulations: Leveraging AI and analytical chemistry to validate and authenticate medicinal plant extracts.
• AI-assisted Plant-Primarily based Drug Discovery: Mining Ayurvedic texts and databases to determine bioactive compounds with therapeutic potential.
• Intestine Microbiome Modulation by Ayurveda: Understanding how Ayurvedic diets and herbs affect intestine microbiota for managing metabolic and autoimmune problems.

v) Genome Diagnostics

• AI-powered danger prediction fashions for diabetes, cardiovascular illnesses, and metabolic problems

• Biomarkers for early most cancers detection, illness development monitoring, and therapy response prediction.

• Single-cell and spatial genomics: Using AI to research single-cell RNA sequencing and spatial transcriptomics for tumor microenvironment profiling and uncommon illness prognosis.

• Genetic danger stratification for neurodegenerative problems: Figuring out genomic and RNA-based signatures related to situations like Alzheimer’s and Parkinson’s to allow early prognosis and intervention.

3. GRANT GUIDELINES

• The issue statements ought to be addressed by data-driven, cutting-edge, multidisciplinary, programmatic analysis initiatives for projected outcomes and will not be for establishing infrastructure/amenities/purposes of AI for screening, disseminating sources/healthcare/schooling and so on. Proposals missing important biotech analysis questions and options and dwelling largely on computational applications or AI/ML strategies is not going to be thought of for help.

• Period: The issue statements ought to be addressed in a two-year interval. A most of Rs 25 crore grant will likely be thought of primarily based on benefit and precise necessities of the proposal.

• This grant shouldn’t be for investigator-driven unbiased analysis efforts and can solely contemplate purposes which might be from inter-disciplinary science groups led by a coordinator with the workforce having demonstrated experience and important analysis results in obtain the specified outcomes.

• The programmatic analysis help is for AI-guided closed loop platforms, during which predictions, experiments and analyses are built-in into the system. Due to this fact, the analysis methodology ought to clearly articulate how the proposed AI primarily based options/choices are analyzed and validated in experimental settings.

• Inter-institutional and inter-disciplinary groups are inspired to come back collectively for organising of hubs in a hub and spoke mannequin.

• It’s anticipated that profitable candidates have the strengths, sources and computational infrastructure to host the AI powered instruments and drive the massive information analytics (computational programmes). Further AI infrastructure mechanism could also be supported by different mechanisms and won’t be funded by grants on this program. Analysis groups are anticipated to deal with advancing capabilities for growth of creating indigenous Massive Language Fashions (LLMs) using neural community information and ‘omics’ information and foundational fashions.

• IP emanating from this system will likely be ruled by the DBT IP Pointers 2023 https://dbtindia.gov.in/regulations-guidelines/tips/dbt-ip-guidelines-2023.

APPLY ONLINE HERE

4. ELIGIBILITY

• Researchers/Scientists working within the Authorities Organizations/ Universities /Tutorial Establishments / Nationwide Laboratories / DSIR acknowledged Non-Revenue Organizations/start-ups/industries with sound scientific & technical backgrounds and related publications within the proposed areas can submit the analysis proposals addressing numerous downside statements. Partnership of academia with trade and start-ups is inspired.

• Tutorial Organisations
  a. Proposals could also be submitted by candidates engaged in analysis actions at numerous Establishments/Universities/Societies/Trusts/NGOs/ Foundations/Voluntary Organizations, acknowledged as a Scientific and Industrial Analysis Group (SIRO).
  b. The Principal investigator will need to have not less than 4 years of the employment remaining within the establishment on the time of proposal submission.

• Trade
  a. Eligibility standards for the industries will likely be as per “Implementation Plan for the Biomanufacturing and Biofoundry Initiative” connected at ANNEXURE I.
  b. Pre-requisite paperwork required to be submitted by the trade as per the BIRAC norms are as follows:

• Corporations/Startups
  a. Incorporation certificates
  b. CA/CS licensed shareholding sample as per BIRAC format (Corporations having a minimal of 51% Indian shareholding /people holding Indian passports are solely eligible) mentioning UDIN quantity.
  c. Particulars relating to in-house R&D facility, if any; or Incubation Settlement with acknowledged Incubator.
  d. Audited monetary particulars of newest final three monetary years.
  e. Copy of passports of the shareholders if required (in help of 51% eligibility standards).

• Restricted Legal responsibility Partnership
  a. Incorporation /Registration Certificates
  b. Partnership deed; CA/CS licensed certificates which states that minimal half of the companions are Indian residents mentioning UDIN quantity.
  c. Copy of passports of Indian companions/subscribers
  d. Analysis mandate/ particulars relating to in-house R&D facility, if any incubation settlement.
  e. Audited monetary particulars of the final three monetary years.
  Corporations/LLP if advisable have to supply a declaration stating that Corporations/LLP shouldn’t be in default of BIRAC OR another group. Additional there are not any Authorized Proceedings going in opposition to the applicant.

5. MODE OF SUBMISSION

Proposals could also be submitted by each Academia and Trade candidates, both independently or as a collaborative challenge.

a. For proposals from Academia/Analysis Establishments/Nationwide Laboratories: candidates ought to submit the proposals within the prescribed format duly forwarded by the government head of the establishment by the Division’s e-ProMIS portal (www.dbtepromis.nic.in).

b. For proposals from Trade and Trade-Academia/ DSIR acknowledged Non-Revenue Organizations/Startups collaboration: candidates ought to submit the proposals within the requisite format duly forwarded by the chief head of the Firm/LLP/Establishment by logging to the BIRAC web site (www.birac.nic.in).

APPLY ONLINE HERE

6. EVALUATION CRITERIA

The proposals will likely be evaluated as per present norms of DBT and BIRAC.

7. FUNDING MODALITIES

a. Tasks having tutorial companions solely will likely be funded by DBT. Tasks involving Academia and Trade or solely trade will likely be supported by BIRAC.
b. Extent of funding will rely upon the proposed actions and will likely be in alignment with the “Implementation Plan for the Biomanufacturing and Biofoundry Initiative” connected at ANNEXURE-1.
c. Undertaking length will likely be upto 2 years.

8. KEY METRICS FOR ASSESSMENT

Key concerns for reviewing the proposals for help would come with:

8.1 Scientific benefit of proposal

• Alignment to name goals and potential to ship novel analysis leads impacting Human well being, Crop manufacturing and Setting.
• Justification for using AI/ML pushed artificial biology/metabolic engineering approached over standard strategies.

8.2 Strategy and methodology

• Relevance of the selection of AI/ML and biotech strategies to the proposed resolution
• Realistically deliberate actions in regard to time and price range
• Integration of a number of analysis companions throughout establishments/disciplines together with startups for delivering outcomes

8.3 Group and investigator capabilities

• Analysis experience and expertise
• Current amenities/infrastructure

8.4 Affect and deliverables

• On the finish of second-year, particular success tales and resourceful challenge leads
• Potential to draw partnerships/investments inside two years and reveal financial impression.

9. PROPOSAL FORMAT AND SUBMISSION

Proposals could also be submitted by each Academia and Trade candidates, both independently or as a collaborative challenge.

• For proposals from Academia/Analysis Establishments: The applying have to be submitted as per the prescribed format duly forwarded by the Head of the establishment by the Division’s e-ProMIS portal (www.dbtepromis.nic.in).
• For proposals from Trade and Trade-Academia collaboration: The applying have to be submitted as per the prescribed format duly forwarded by the Head of the Firm/Establishment by logging to the BIRAC web site (www.birac.nic.in).

10. CONTACT INFORMATION

For queries relating to the grant, contact:

Dr. Kalaivani Ganesan, Scientist F, DBT @ [email protected]; [email protected]
Dr. Amit Katiyar, Chief Supervisor IP & TM, BIRAC @ [email protected]

For Technical queries in on-line submission, please write to: DBT Software help – e-promise workforce, Tel: 011-24365136, [email protected]

Final date for submission of proposals is tenth Could, 2025.

APPLY ONLINE HERE

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